Bioassay of tetraethylthiuram disulfide for possible carcinogenicity.

by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Publisher: Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md

Written in English
Published: Pages: 100 Downloads: 90
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Subjects:

  • Carcinogens.,
  • Plasticizers -- Toxicology.,
  • Vulcanization accelerators -- Toxicology.

Edition Notes

Bioassay of tetraethylthiuram disulfide for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Get this from a library. Bioassay of tetraethylthiuram disulfide for possible carcinogenicity. [National Bioassay of tetraethylthiuram disulfide for possible carcinogenicity.

book Institute (U.S.). Division of Cancer Cause and Prevention.]. Author(s): Frederick Cancer Research Center.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of tetraethylthiuram disulfide for possible carcinogenicity.

IV SUMMARY A bioassay of butylated hydroxytoluene (BHT) for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice.

Groups of 50 rats and 50 mice of each sex were administered BHT at one of two doses, either 3, or 6, ppm; the rats for weeks and the mice for or weeks. Disulfiram, the corresponding disulfide of diethyldithiocarbamate, was effective at concentrations 1, times lower (1X vs 1X M).

Disulfiram, but not diethyldiethiocarbamate, reacted very efficiently with synaptosomal protein thiols; both diethyldithiocarbamate and disulfiram induced uptake inhibition could be reversed by the thiol.

Bioassay of Tolazamide for Possible Carcinogenicity. NCI Carcinogenesis Technical Report, No. Bioassay of Tetraethylthiuram Disulfide for Possible by: National Cancer Institute, c, Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity, NCI Technical Report Series No.

U.S. Dept. Health, Education and Welfare, Public Health Service, National Institute of Health, Washington. Google ScholarCited by: Thiram was rapidly absorbed from the gastrointestinal tract and the lungs and rapidly distributed in the body (O'Donoghue ).In Sprague Dawley rats, intraperitoneal thiram injections of 15 to 60 mg/kg body weight produced increased CS 2 values in the exhaled air within up to two hours.

Increasing the dose from 15 to 30 mg/kg body weight produced a tenfold increase in CS 2 values in the. 12 thiuram and dithiocarbamate compounds used in the rubber industry as accelerators, and to some extent as sources of sulfur, were tested, as well as carbon disulfide, a metabolite found in vivo after dithiocarbamate treatment, for mutagenicity in Salmonella typhimurium.A mutagenic effect on the base-substitution-sensitive strains TA and TA was found for 7 by: @article{osti_, title = {In vitro toxicity of welding fumes and their constituents}, author = {Stern, R M and Hansen, K and Madsen, A F and Olsen, K M}, abstractNote = {Welding fumes from a wide variety of processes and applications were assayed for toxicity with BHK21 cell line and SHE primary cells in culture.

The most toxic fumes are those from the manual metal arc welding of. Therapy with the alcohol deterrent disuifiram (tetraethylthiuram disulfide, TETD) caused a delayed ethanol elimination from the blood of human subjects (Peachey et al~ ).

The aim of this study was to evaluate the possible genotoxicity of three cryoprotectants extensively used for oocyte vitrification: dimethyl sulfoxide (DMSO), ethylene glycol (EG) and propylene.

Full text of "Monthly catalog of United States government publications" See other formats. Carcinogenicity The carcinogenicity of ETU has been evaluated by IARC (, ).

It was classified in group 2B, i.e., limited evidence for activity in short-term tests; sufficient evidence for carcinogenicity in animals; inadequate evidence for carcinogenicity in human beings. EPA/1- October VAPOR-PHASE ORGANIC POLLUTANTS VOLATILE HYDROCARBONS AND OXIDATION PRODUCTS Panel on Vapor-Phase Organic Pollutants Committee on Medical and Biologic Effects of Environmental Pollutants National Research Council Washington, D.C.

20Ul8 Contract No. ^2 Project Officer F. Gordon Hueter Criteria and Special Studies Office Health Effects. This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. Natural rubber latex allergy was also relatively frequent (%).

The major substances causing ACD were rubber glove chemicals (thiuram mix and tetraethylthiuram disulfide), preservatives (formaldehyde, formaldehyde releasers, and isothiazolinones), excipients in hand cleansers, which are hard-to-avoid weak allergens, and antiseptics.

The study authors asserted that the Antabuse syndrome is not likely to occur in subjects who have blood alcohol levels of up to % and are exposed to 10 ppm carbon disulfide. The possible role of the ethanol-inducible isozyme of cytochrome P in the metabolism of carbon disulfide has been examined (Snyderwine et al.

N-Nitrosodimethylamine is found in pepper (Capsicum annuum).N-Nitrosodimethylamine is a food contaminant especially in cured meat products. N-Nitrosodimethylamine (NDMA), also known as dimethylnitrosamine (DMN), is a semi-volatile organic chemical that is highly toxic and is a suspected human carcinogen.

syns: accel r 0 bismorpholino disulfide 0 dimorpholine disulfide 0 dimorpholino disulfide 0 dithiobismorpholine 0 4,4'dithiobis(morph0line) 0 n,n-dithiodimorpholine 0 4,4'-dithiodimorpholine 0 4,4'dithiomorpholine 0 morpholine disulfide 0 morpholinodisulfide 0 sulfasan 0 sulfasan r powder 0 usaf b 0 usaf ek-t (CEMA) in the urine as a possible indicator of exposure to acrylonitrile.

Ind. Med. Maltoni C, Ciliberti A, and Di Maio V. Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion. Med. Lav. 68(6) Maltoni C, Ciliberti A, Cotti G, and Perino G.

Long-term. This book contains information obtained from authentic and highly regarded sources. on improving the information provided as well as suggestions for additional material which could be included in possible future editions of this handbook.

In this respect, the CRC Handbook of Toxicology, Second Edition has been extensively updated and. Table 4 POSSIBLE NEW COHORTS IN SF-0 SMSA Group Approximate No. persons State of Califor Operating Engineers 6, Teamsters 6, Contra Costa County 6, State University 4, Apprentices 3, American Chemical Society 2, Oil, Chemical, Atomic Workers () 1, Int'l Association Flight Attendants 1, City of.

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The book includes an introduction to the regulations governing the labelling and use of chemicals, together with definitions of toxicity, carcinogenicity, mutagenicity and effects on reproduction. Specific hazard, risk and safety labels are explained.

The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis.